Kinship, as an organizing principle, gives structure to communities and cultures—and it can vary as widely as the social relationships organized in its name. Making Relatives of Them examines kinship among the Great Lakes Native nations in the eventful years of the late eighteenth and early nineteenth century, revealing how these Indigenous peoples’ understanding of kinship, in complex relationship with concepts of gender, defined their social, political, and diplomatic interactions with one another and with Europeans and their descendants.